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Number of reactions per 10,000 doses sold between 2010-2014 (that were reported), please note that some people do not record adverse reactions so numbers could be significantly higher: It again is highlighted that protective and susceptible gene halotypes have been identified in dogs demonstrating genetic predispositions to hypersensitivities and adverse reactions to vaccinations
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Recent single‐cell sequencing studies have revealed that with hair follicle cycle disruption, the number of immune subsets such as macrophages, mast cells, and NK cells dynamically changes, highlighting the interaction between immune attack and hair follicle cycle disruption in the pathogenesis of AA [142, 143, 144, 145]